Food Poisoning Vaccines May Be On The Horizon
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Salmonella has dominated the news as of late. Once an illness thought to come only from runny eggs and raw chicken, it has now been found in a wide variety of foods including peanuts, dried gelatin, and, bizarrely, frog legs. The recent PCA Salmonella outbreak was perhaps the largest in history.
Salmonella has been around for a long time, causing illness in humans for at least one hundred years. Now, science may be on the verge of finding a vaccine. The fight for a vaccine is taking place in labs across our world – as well as in others beyond it.
Astronauts have been conducting Salmonella experiments aboard the International Space Station with results that have been both surprising and promising. Previous studies have shown that weightlessness can have a dangerous affect on bacteria and pathogens. Early data indicated that Salmonella became much more virulent in a zero gravity environment. The studies were conducted as a corollary to the well documented loss of immunity in micro-gravitational environments and the fear that astronauts might be more susceptible to food-borne illness.
Further research, however, has led to the discovery that Salmonella’s virulence can not only be controlled, it can actually be turned off. The discovery sent shockwaves through the scientific community and carries with it incredible ramifications.
If the infectious part of Salmonella can be negated, then it is possible for the pathogen to be introduced to our bodies without causing illness. This, potentially, would allow our immune system to develop immunity without ever having to experience the symptoms.
Here on Earth, at the Institute of Food Research in Norwich, UK, researchers are also close to finding a vaccine. They have shown, after a number of breakthroughs that Salmonella relies on glucose for its own survival during the infection stage. While seemingly trivial, the discovery allows for the possibility of a vaccine not just against Salmonella and other food-borne pathogens, but also a range of other superbugs.
“This is the first time that anyone has identified the nutrients that sustain Salmonella while it is infecting a host’s body,” said Dr. Arthur Thompson, IFR group leader. “Our experiments showed that glucose is the major sugar used by Salmonella during infection,” said Dr Thompson.
Scientists believe they can turn off the cells ability to absorb glucose which would render them incapable of replicating. The salmonella would, however, continue to stimulate an immune response which would eventually lead to immunity.
